Tyrosinase inhibitors are a class of compounds that block the production of melanin, the pigment that gives skin, hair, and eyes their color. They are often used in skin care products to lighten hyperpigmentation, such as age spots, melasma, and freckles. They can also be used in hair care products to lighten dark hair.

One of the most potent tyrosinase inhibitors is hydroquinone, which is used to treat hyperpigmentation caused by conditions such as melasma and post-inflammatory hyperpigmentation. However, there is some controversy surrounding the safety of hydroquinone, and it should only be used under the guidance of a healthcare provider.

Other tyrosinase inhibitors that are commonly used in skincare products include kojic acid, arbutin, and vitamin C. These ingredients work by inhibiting the production of melanin, which can help to even out skin tone and reduce the appearance of dark spots.

There are a number of different tyrosinase inhibitors available, including:

  • Hydroquinone: Considered the most potent tyrosinase inhibitor, hydroquinone is a synthetic ingredient used to treat hyperpigmentation caused by conditions such as melasma and post-inflammatory hyperpigmentation. It works by inhibiting the production of melanin in the skin.
  • Arbutin: A natural ingredient derived from the bearberry plant, arbutin is a tyrosinase inhibitor that helps to even out skin tone and reduce the appearance of dark spots. It works by inhibiting the activity of the enzyme tyrosinase, which is involved in the production of melanin.
  • Kojic acid: Another natural ingredient derived from fungi, kojic acid is a tyrosinase inhibitor that is commonly used in skincare products to lighten dark spots and even out skin tone. It works by blocking the production of melanin in the skin.
  • Licorice extract: Derived from the root of the licorice plant, licorice extract contains a compound called glabridin, which has been shown to have tyrosinase inhibiting properties. It is often used in skincare products to lighten dark spots and even out skin tone.
  • Mulberry extract: Another natural ingredient, mulberry extract contains compounds called flavonoids that have been shown to have tyrosinase inhibiting properties. It is often used in skincare products to brighten and even out skin tone.
  • White willow bark extract: Derived from the bark of the white willow tree, this natural ingredient contains salicin, which has been shown to have tyrosinase inhibiting properties. It is often used in skincare products to improve skin tone and reduce the appearance of dark spots.
  • Alpha-arbutin: A synthetic ingredient derived from the bearberry plant, alpha-arbutin is a tyrosinase inhibitor that is more stable and effective than traditional arbutin. It helps to even out skin tone and reduce the appearance of dark spots.
  • Beta-arbutin: Similar to alpha-arbutin, beta-arbutin is a synthetic ingredient derived from the bearberry plant. It is a tyrosinase inhibitor that helps to even out skin tone and reduce the appearance of dark spots.
  • Magnesium ascorbyl phosphate (MAP): A stable form of vitamin C, MAP is a powerful antioxidant that has been shown to have tyrosinase inhibiting properties. It is often used in skincare products to brighten and even out skin tone.
  • N-acetylcysteine (NAC): An amino acid that has been shown to have tyrosinase inhibiting properties, NAC is often used in skincare products to reduce the appearance of dark spots and even out skin tone.
  • Tranexamic acid: Originally developed as a medication to treat blood clots, tranexamic acid has been shown to have tyrosinase inhibiting properties. It is often used in skincare products to reduce the appearance of dark spots and even out skin tone.
  • Vitamin C: A powerful antioxidant that has been shown to have tyrosinase inhibiting properties, vitamin C is often used in skincare products to brighten and even out skin tone. It also helps to protect the skin from environmental stressors like pollution and UV radiation.
To effectively treat hyperpigmentation, it is often necessary to use multiple tyrosinase inhibitors. That is why you may see more than one anti-hyperpigmentation ingredient listed on the ingredient label of these products.